Dr. Rudman's Clinical Findings

In July 1990, Dr. Daniel Rudman published his landmark clinical findings on the effects of hGH in the New England Journal of Medicine. The results were exciting and startling!

Effects of hGH in men over 60 years of age

The declining activity of the growth hormone-insulin-like growth factor 1 (IGF-1) with advancing age may contribute to the decrease in lean body mass and the increase in mass of adipose tissue that occur with aging.

"The overall deterioration of the body that comes with growing old is not inevitable ... We now realize that some aspects of it can be prevented or reversed."

Dr. Daniel Rudman, M.D.

Trial Methods Used by Rudman

To test this hypothesis, Dr. Rudman, studied IGF-1 plasma while working with volunteers aged 61 to 81 at the Medical College of Wisconsin-Milwaukee. Dr. Rudman used hGH manufactured synthetically to replicate what is created naturally in the body's own pituitary gland.

During the treatment period, 12 men (group 1) received approximately 0.03 mg of biosynthetic human growth hormone per kilogram of body weight subcutaneously three times a week, and 9 men (group 2) received no treatment. Plasma IGF-1 levels were measured monthly. At the end of each period, Dr. Rudman's team measured lean body mass, the mass of adipose tissue, skin thickness (epidermis plus dermis), and bone density at nine skeletal sites.

Observations

Of the group who received treatment, their mean plasma IGF-1 levels rose back to youthul ranges (500-1500 U/liter), while the second group remained below (350 U/liter).

Also, in the group that received treatment for six months, it was observed that they showed an 8.8 percent increase in lean body mass, a 14.4 percent decrease in adipose-tissue mass, and a 1.6 percent increase in average lumbar vertebral bone density. Skin thickness increased .1 percent. The second group showed no significant change in lean body mass, the mass of adipose tissue, skin thickness, or bone density during treatment.

Dr. Rudman's Conclusions

Diminished secretion of growth hormone is responsible in part for the decrease of lean body mass, the expansion of adipose-tissue mass, and the thinning of the skin that occurs in old age. (New England Journal of Medicine, 1990; 323:1-6)

In middle and late adulthood, all people experience a series of progressive alterations in body composition. The lean body mass shrinks and the mass of adipose tissue expands. The contraction in lean body mass reflects atrophic processes in skeletal muscle, liver, kidney, spleen, skin, and bone.

These structural changes have been considered unavoidable results of aging. It has recently been proposed, however, that reduced availability of growth hormone in late adulthood may contribute to such changes.

These alterations in body composition caused by growth hormone deficiency can be reversed by replacement doses of the hormone, as experiments in children, and adults 20 to 50 years old have shown. These findings suggest that the atrophy of the lean body mass and its component organs and the enlargement of the mass of adipose tissue that are characteristic of the elderly result at least in part from diminished secretion of growth hormone. If so, the age-related changes in body composition should be correctable in part by the administration of human growth hormone, now readily available as a biosynthetic product.

Dr. Daniel Rudman joined the Medical College of Wisconsin, where this study was conducted, in 1988 as Professor and Associate Chief of Staff for Geriatrics and Extended Care at the Zablocki VA Medical Center. He continued his human nutrition research with the elderly until his untimely death in 1994. Dr. Rudman's life and creativity as a clinical investigator was highlighted by his ability to focus basic knowledge on important problems in clinical medicine.

Advanced Clinical hGH Studies

Since Dr. Rudman's initial findings, thousand of additional studies have supported the fact the hGH not only retards aging, but reverses the process as well.

Injectable hGH was first approved by the FDA for children suffering from dwarfism. In August 1996 the FDA approved hGH injections as anti-aging therapy with a doctors prescription. This could cost anywhere from $15,000 to $20,000 a year, and only movie stars and other wealthy individuals could obtain it and take advantage of the costly program.

Today hGH is made in the laboratory by genetic engineering methods generating an identical protein to the one made naturally in the human body. Allergic reactions are rare and it is extremely safe for adult use.


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